Wadhwani Foundation was founded in 2000 by Silicon Valley based entrepreneur and philanthropist, Dr. Romesh Wadhwani with the primary mission of accelerating economic development in emerging economies through large-scale job creation. The Foundation is present in Asia, Africa and Latin America operating in association with governments, corporates, mentors, investors and educational institutes. Its Initiatives are driving job creation through entrepreneurship, skills development and innovation.

National Entrepreneurship Network (NEN) inspires, educates, and supports entrepreneurs to create high-value companies and jobs. NEN creates city-based entrepreneurial ecosystems consisting of institutes that teach entrepreneurship and network of mentors, investors, and incubators that support startups and SMEs. NEN also aims to create world-class innovation ecosystems in critical sectors of high importance in India through govt. supported innovation grants to 25,000 companies over five years as part of the Startup and Small Business Innovation initiative (SSBI).

Global Innovation Network (GIN) aims to create world-class research institutes addressing the challenges in emerging economies that also lead to creation of global organizations. The Wadhwani Research Centre for Biotechnology (WRCB) established at IIT Bombay, is leveraging bioengineering research in areas of low-cost bio-sensors, biomedical devices and drug delivery, and bioinformatics. Shanta Wadhwani Center for Cardiac and Neural Research (SWCCNR) established at the National Center for Biological Sciences (NCBS) addresses major problems in cardiac and neurodevelopmental biology aimed at understanding the role of stem cells in neuroscience and cardiomyopathies.

Policy Research Network (PRN) provides data-driven research inputs for informed policy action focused on innovation, entrepreneurship, skills development and employment aimed at accelerating economic growth.